ALPHA-COCAINE

Silent Cocaine Poisoning

Background: Cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. Absence of clinical manifestations in cocaine poisoning is unusual. Case report: A 26-year old man, known to be a cocaine addict, declared that he was forced by cocaine dealers to swallow many tablets of cocaine, six hours prior to admission to emergency departm...

a comparison of dexmedetomidine, moxonidine and alpha-methyldopa effects on acute, lethal cocaine toxicity

conclusions the present study provides the first experimental evidence in support of dexmedetomidine treatment for cocaine-induced seizures. premedication with dexmedetomidine reduces seizure activity in a mouse model of acute cocaine toxicity. in addition, while dexmedetomidine may be effective, moxonidine and alpha-methyldopa did not effectively prevent cocaine-induced lethality. results the ...

Cocaine

Cocaine.

Cocaine, derived from the shrub Erythroxylon coca, was both chemically extracted and reported to be psychotogenic in 1859. Included in the original formulation of ‘Coca-Cola’, it was declared illegal under the Harrison Act of 1914. It has been used as a local anaesthetic and in analgesic cocktails. In one study, the main routes of administration were: smoking, 40%; intranasal, 32%; and injectin...

Cocaine and exercise: alpha-1 receptor blockade does not alter muscle glycogenolysis or blood lactacidosis.

In our previous work, we routinely observed that a combined cocaine-exercise challenge results in an abnormally rapid muscle glycogen depletion and excessive blood lactacidosis. These phenomena occur simultaneously with a rapid rise in norepinephrine and in the absence of any rise in epinephrine. We postulated that norepinephrine may cause vasoconstriction of the muscle vasculature through acti...